| Name： | VERAPAMIL HYDROCHLORIDE |
| CAS： | 52-53-9 ;152-11-4 ;23313-68-0 |
| Synonyms： | IPROVERATRIL ; ISOPTIN ; 5-[N-(3,4-DIMETHOXYPHENYLETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE ; IPROVERATRIL HYDROCHLORIDE ; VERAPAMIL HCL ; 2-(3,4-DIMETHOXYPHENYL)-5-([2-(3,4-DIMETHOXYPHENYL)ETHYL](METHYL)AMINO)-2-(PROPAN-2-YL)PENTANENITRILE HYDROCHLORIDE ; 2-(3,4-DIMETHOXYPHENYL)-5-[[2-(3,4-DIMETHOXYPHENYL)ETHYL](METHYL)AMINO]-2-ISOPROPYLPENTANENITRILE HYDROCHLORIDE ; ISOPTIN HYDROCHLORIDE ; CALAN ; 2-(3,4-DIMETHOXYPHENYL)-5-([2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO)-2-(METHYLETHYL)PENTANENITRILE, CHLORIDE ; ARPAMYL HYDROCHLORIDE ; VERAPAMIL (HYDROCHLORIDE) ; (+/-)-VERAPAMIL HYDROCHLORIDE ; VIPROVERATRIL ; 5-((3,4-DIMETHOXYPHENETHYL)(METHYL)AMINO)-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLPENTANENITRILE HYDROCHLORIDE ; CALAN HYDROCHLORIDE ; 5-((3,4-DIMETHOXYPHENETHYL)METHYLAMINO)-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE ; (±)-VERAPAMIL HYDROCHLORIDE ; ALPHA-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4-DIMETHOXY-ALPHA-(1-METHYLETHYL)-BENZENEACETONITRILE HYDROCHLORIDE ; VERAPAMIL HYDROCHLORIDE ; BENZENEACETONITRILE, ALPHA-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-3,4-DIMETHOXY-A-(1-METHYLETHYL)-, MONOHYDROCHLORIDE |
| MDL.： | MFCD00055208 |
| H bond acceptor： | 6 |
| H bond donor： | 0 |
| Smile： | CC(C)C(CCCN(C)CCc1ccc(c(c1)OC)OC)(C#N)c2ccc(c(c2)OC)OC.Cl |
| InChi： | InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H |
| InChiKey： | InChIKey=DOQPXTMNIUCOSY-UHFFFAOYSA-N |
Property |
|
| Melting Point： | 142 DEG C (DEC)(LIT)/140-144℃ |
| Comments： | BIOCHEM/PHYSIOL ACTIONS: ALPHA1-ADRENOCEPTOR ANTAGONIST BIOCHEM/PHYSIOL ACTIONS: L-TYPE CALCIUM CHANNEL BLOCKER. BLOCKS L-TYPE CA2+ CHANNELS IN SMOOTH AND CARDIAC MUSCLE, INDUCES APOPTOSIS OF HUMAN PRIMARY AND METASTATIC COLON ADENOCARCINOMA CELLS IN VITRO. DRUG RESISTANCE REVERSAL AGENT ACTING ON PGP, EG DECREASE RENAL TUBULE ELIMINATION OF DIGOXIN. INCREASES BASAL ATPASE ACTIVITY OF PGP. SUBSTRATE OF CYP3A4 AND CYP2C6 RIDADR: UN 2811 6.1/PG 3 RTECS: YV8320000 UNSPSC: 12352100 WGK: 3 |
Safety information |
|
| Symbol： |
GHS06
|
| Signal word： | Danger |
| Hazard statements： | H301 + H311 + H331 |
| Precautionary statements： | P261-P280-P301 + P310-P311 |
| hazard symbol： | T |
| Risk Code： | R:23/24/25 |
| Safe Code： | S:36/37-45 |
| UN Code： | 2811 |
| WGK Germany： | 3 |
VERAPAMIL HYDROCHLORIDE
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