| Name： | TRIAMCINOLONE |
| CAS： | 124-94-7 |
| Synonyms： | TRIADERM ; (8S,9R,10S,11S,13S,14S,16R,17S)-9-FLUORO-11,16,17-TRIHYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE ; 9ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRAHYDROXY-1,4-PREGNADIENE-3,20-DIONE ; 1,4-PREGNADIEN-9ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETROL-3,20-DIONE ; FLUOXYPREDNISOLONE ; TRIAMCINOLONE ; KENACORT ; 9ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE ; TRI-NASAL |
| MDL.： | MFCD00010477 |
| H bond acceptor： | 6 |
| H bond donor： | 4 |
| Smile： | C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)CCC4=CC(=O)C=C[C@@]43C)F)O |
| InChi： | InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1 |
| InChiKey： | InChIKey=GFNANZIMVAIWHM-OBYCQNJPSA-N |
Property |
|
| Melting Point： | 262-263 DEG C(LIT) |
| Comments： | BIOCHEM/PHYSIOL ACTIONS: IMPAIRS TUMOR NECROSIS FACTOR (TNF)-ALPHA-INDUCED DEGRADATION OF KAPPAB-ALPHA BIOCHEM/PHYSIOL ACTIONS: INDUCES GENE EXPRESSION AND APOPTOSIS BIOCHEM/PHYSIOL ACTIONS: INHIBITS PROSTAGLANDIN SYNTHESIS BIOCHEM/PHYSIOL ACTIONS: POTENTIATES THE DIFFERENTIATION-INDUCING EFFECTS OF BONE MORPHOGENETIC PROTEINS (BMP-2, -4, -6) BIOCHEM/PHYSIOL ACTIONS: TRIAMCINOLONE IS A SYNTHETIC GLUCOCORTICOID AGONIST OPTICAL ACTIVITY: [ALPHA]25/D +69 DEG, C = 2 IN DMF RTECS: TU3850000 UNSPSC: 12352100 WGK: 3 |
Safety information |
|
| Symbol： |
GHS08
|
| Signal word： | Warning |
| Hazard statements： | H351 |
| Precautionary statements： | P281 |
| hazard symbol： | Xn |
| Risk Code： | R:40 |
| Safe Code： | S:22-36 |
| WGK Germany： | 3 |
TRIAMCINOLONE
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