| Name： | METHOTREXATE HYDRATE |
| CAS： | 133073-73-1 ;59-05-2 |
| Synonyms： | 4-AMINO-10-METHYLFOLIC ACID HYDRATE ; (+)-AMETHOPTERIN HYDRATE ; METHOXTREXATE ; MTX HYDRATE ; METHOTREXATE HYDRATE ; L-(+)-AMETHOPTERIN HYDRATE ; L-AMETHOPTERIN HYDRATE ; METHYLAMINOPTERIN HYDRATE ; L-(+)-4-AMINO-N10-METHYLPTEROYLGLUTAMIC ACID HYDRATE ; ANTIFOLAN HYDRATE ; METHOTREXATE ; L-4-AMINO-N10-METHYLPTEROYLGLUTAMIC ACID HYDRATE ; TETRACALCIUM PHOSPHATE |
| MDL.： | MFCD00150847 |
| H bond acceptor： | 13 |
| H bond donor： | 5 |
| Smile： | CN(Cc1cnc2c(n1)c(nc(n2)N)N)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O |
| InChi： | InChI=1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1 |
| InChiKey： | InChIKey=FPJYMUQSRFJSEW-ZOWNYOTGSA-N |
Property |
|
| Comments： | APPLICATION: POTENT INHIBITOR OF DIHYDROFOLATE REDUCTASE AND AGENT FOR ANTITUMOR STUDIES. USE TO INHIBIT DIHYDROFOLATE REDUCTASE IN DHFR-BASED PROTEIN EXPRESSION SYSTEMS. ALSO EFFECTIVE IN TREATMENT OF PYRIMETHAMINE-RESISTANT PLASMODIUM VIVAX MALARIA PARASITES APPLICATION: POTENT INHIBITOR OF DIHYDROFOLATE REDUCTASE AND AGENT FOR ANTITUMOR STUDIES. USE TO INHIBIT DIHYDROFOLATE REDUCTASE IN DHFR-BASED PROTEIN EXPRESSION SYSTEMS. ALSO SHOWS IMMUNOSUPPRESSIVE EFFECTS IN, EG, RHEUMATOID ARTHRITIS OPTICAL ACTIVITY: [ALPHA]25/D +17 DEG, C = 1 IN 0.05 M NA2CO3 RIDADR: UN 1544 6.1/PG 3 UNSPSC: 12352100 WGK: 3 |
Safety information |
|
| Symbol： |
GHS06
GHS08
|
| Signal word： | Danger |
| Hazard statements： | H301-H315-H319-H360 |
| Precautionary statements： | P201-P301 + P310-P305 + P351 + P338-P308 + P313 |
| hazard symbol： | T |
| Risk Code： | R:61-25-36/38 |
| Safe Code： | S:53-26-36/37-45 |
| WGK Germany： | 3 |
METHOTREXATE HYDRATE
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