| Name： | METFORMIN HYDROCHLORIDE |
| CAS： | 1115-70-4 |
| Synonyms： | METFORMIN (HYDROCHLORIDE) ; N,N-DIMETHYLIMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE ; GLUCOFORM, HYDROCHLORIDE ; DIABETOSAN, HYDROCHLORIDE ; DIABEX, HYDROCHLORIDE ; METFORMIN HYDROCHLORIDE ; 1,1-DIMETHYLBIGUANIDE HYDROCHLORIDE ; 1-CARBAMIMIDAMIDO-N,N-DIMETHYLMETHANIMIDAMIDE HYDROCHLORIDE ; METFORMIN ; DIABEX ; GLUCOMINE, HYDROCHLORIDE ; GLUCOMET, HYDROCHLORIDE ; METFORMIN HCL ; METFORMIN HYDROCHLORIDE, 99% PHARMACEUTICAL GRADE ; RIOMET ; METIGUANIDE, HYDROCHLORIDE ; GLUCOMIN, HYDROCHLORIDE ; SIAMFORMET, HYDROCHLORIDE ; N,N-DIMETHYLIMIDODICARBONIMIDIC DIAMINE HYDROCHLORIDE ; DIABETOSAN ; ORABET, HYDROCHLORIDE ; GLUCOPHAGE, HYDROCHLORIDE ; GLUCOPHAGE ; WALAPHAGE, HYDROCHLORIDE |
| MDL.： | MFCD00012582 |
| H bond acceptor： | 5 |
| H bond donor： | 4 |
| Smile： | CN(C)C(=N)NC(=N)N.Cl |
| InChi： | InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H |
| InChiKey： | InChIKey=OETHQSJEHLVLGH-UHFFFAOYSA-N |
Property |
|
| Melting Point： | 223-226 DEG C(LIT) |
| Comments： | BIOCHEM/PHYSIOL ACTIONS: METFORMIN IS AN ANTIDIABETIC AGENT THAT REDUCES BLOOD GLUCOSE LEVELS AND IMPROVES INSULIN SENSITIVITY. ITS METABOLIC EFFECTS, INCLUDING THE INHIBITION OF HEPATIC GLUCONEOGENESIS, ARE MEDIATED AT LEAST IN PART BY ACTIVATION OF THE LKB1-AMPK (AMP-ACTIVATED PROTEIN KINASE) PATHWAY. ACTIVATION OF THIS PATHWAY ALSO APPEARS TO BE INVOLVED IN THE ANTIPROLIFERATIVE AND PROAPOPTOTIC ACTIONS OF METFORMIN IN CANCER CELL LINES FREQUENTLY ASKED QUESTIONS: LIVE CHAT AND FREQUENTLY ASKED QUESTIONS ARE AVAILABLE FOR THIS PRODUCT RTECS: DU1800000 UNSPSC: 12352100 WGK: 3 |
Safety information |
|
| Symbol： |
GHS07
|
| Signal word： | Warning |
| Hazard statements： | H302-H315-H319 |
| Precautionary statements： | P305 + P351 + P338 |
| hazard symbol： | Xn |
| Risk Code： | R:22-36/38 |
| Safe Code： | S:26-36 |
| WGK Germany： | 3 |
METFORMIN HYDROCHLORIDE
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