| Name： | CABERGOLINE |
| CAS： | 81409-90-7 |
| Synonyms： | 1-[(6-ALLYLERGOLINE-8BETA-YL)CARBONYL]-1-[3-(DIMETHYLAMINO)-PROPYL]-3-ETHYLUREA ; N-[3-(DIMETHYLAMINO)PROPYL]-N-[(ETHYLAMINO)CARBONYL]-6-(2-PROPENYL)ERGOLINE-8-CARBOXAMIDE ; CABERGOLINE ; CABERGOLINE？ ; (8BETA)-N-[3-(DIMETHYLAMINO)PROPYL]-N-[(ETHYLAMINO)CARBONYL]-6-(2-PROPEN-1-YL)-ERGOLINE-8-CARBOXAMIDE ; DOSTINEX ; CABASER ; 1-ETHYL-3-(3'-DIMETHYLAMINOPROPYL)-3-(6'-ALLYLERGOLINE-8'BETA-CARBONYL)UREA |
| MDL.： | MFCD00867887 |
| H bond acceptor： | 7 |
| H bond donor： | 2 |
| Smile： | CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(c[nH]4)C[C@H]2N(C1)CC=C |
| InChi： | InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1 |
| InChiKey： | InChIKey=KORNTPPJEAJQIU-KJXAQDMKSA-N |
Property |
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| Comments： | BIOCHEM/PHYSIOL ACTIONS: CABERGOLINE, A LYSERGIC ACID AMIDE DERIVATIVE, IS A POTENT DOPAMINE D2 RECEPTOR AGONIST. IT ALSO ACTS ON DOPAMINE RECEPTORS IN LACTOPHILIC HYPOTHALAMUS CELLS TO SUPPRESS PROLACTIN PRODUCTION IN THE PITUITARY GLAND. IT HAS BEEN USED FOR MONOTHERAPY OF PARKINSON'S DISEASE IN THE EARLY PHASE BIOCHEM/PHYSIOL ACTIONS: COMBINATION THERAPY, TOGETHER WITH LEVODOPA AND A DECARBOXYLASE INHIBITOR SUCH AS CARBIDOPA, IN PROGRESSIVE-PHASE PARKINSON'S DISEASE AND ADJUNCTIVE THERAPY OF PROLACTIN-PRODUCING PITUITARY GLAND TUMORS (MICROPROLACTINOMAS) GENERAL DESCRIPTION: THIS PRODUCT IS PROVIDED AS DELIVERED AND SPECIFIED BY THE ISSUING PHARMACOPOEIA. ALL INFORMATION PROVIDED IN SUPPORT OF THIS PRODUCT, INCLUDING MSDS AND ANY PRODUCT INFORMATION LEAFLETS HAVE BEEN DEVELOPED AND ISSUED UNDER THE AUTHORITY OF THE ISSUING PHARMACOPOEIA. FOR FURTHER INFORMATION AND SUPPORT PLEASE GO TO THE WEBSITE OF THE ISSUING PHARMACOPOEIA OTHER NOTES: SALES RESTRICTIONS MAY APPLY |
Safety information |
|
| Symbol： |
GHS07
|
| Signal word： | Warning |
| Hazard statements： | H302-H315-H319-H335 |
| Precautionary statements： | P261-P305 + P351 + P338 |
| hazard symbol： | Xi |
| Risk Code： | R:36/37/38 |
| Safe Code： | S:26-36/37 |
| WGK Germany： | 3 |
CABERGOLINE
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