| Name： | BG-45 |
| CAS： | 926259-99-6 |
| Synonyms： | BG45 ; BG-45 ; N-(2-AMINOPHENYL)-2-PYRAZINECARBOXAMIDE |
| H bond acceptor： | 0 |
| H bond donor： | 0 |
| Smile： | NC1=C(C=CC=C1)NC(=O)C1=NC=CN=C1 |
| InChi： | InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16) |
| InChiKey： | InChIKey=LMWPVSNHKACEKW-UHFFFAOYSA-N |
Property |
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| Comments： | BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50?= 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma |
| Specification： | BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50= 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). |
Safety information |
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BG-45
TradePlatform@qq.com
| Supplier | ||
|---|---|---|
| Custom | info@chems.com.cn | +86 (0)187 533 888 68 |
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